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Sunday, July 21, 2013

Food-borne microbe may cause cancer

Cancer Defeated Publications

Could E. Coli Bacteria be Both a Cancer CAUSE and a Cancer CURE?


    When you hear the words E. coli, the first thing you probably think of is food poisoning. And you wouldn't be wrong—given that some strains of the bacteria have been linked to food recalls and serious illness.

    Well, it might surprise you to learn there are harmless strains of the Escherichia colibacteria that are a normal part of your intestinal flora — the "good" bacteria in your colon.

    In fact, the good strains of E. coli can help you by producing vitamin K, a valuable nutrient that's only recently started to get the attention it deserves (I take it as a supplement every day). E. coli can also keep harmful bacteria from setting up camp in your intestines.

    So if E. coli can be so friendly—why are we talking about its connection to cancer? Glad you asked. . .keep reading. . .

Continued below...


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Cancer Defeated Publications

    New research suggests that the normally harmless E. coli may change its nature if your gut is inflamed.

    It seems that patients with inflammatory bowel syndrome (IBS) develop colorectal cancer at significantly higher rates than people who don't have this digestive problem.

    And one study from scientists at the University of North Carolina at Chapel Hill links this phenomenon with the presence of a strain of E. coli.

    Christian Jobin, PhD, associate professor in the Division of Gastroenterology and Hepatology, led a team that raised mice with a gene mutation that makes them susceptible to inflammatory bowel disease.

    After rearing the mice in germ-free cages, the scientists moved them to cages where bacteria-filled mice formerly lived.

    According to results published in the journal Science, five months later, all of the mutant mice had developed bowel disease.

    What's more, the researchers found that 60 to 80 percent of the animals had developed colon cancer!

    One common thread in the mutant mice was that they'd all developed a gut environment containing a much higher than normal proportion of E. coli.

    And one E. coli strain that stood out was NC101, which was linked to aggressive forms of bowel disease in mice. This E. coli bacterium also produces the DNA-damaging protein colibactin.

    In addition to these harmful bacteria, the researchers also found strains of E. coli in the gut that did not make colibactin.

    These other bacteria were associated with bowel disease—but did not contribute to tumor formation.
How does this relate to colon cancer in humans?
    Humans also can harbor the bacteria that produce colibactin. The North Carolina investigators found these bacteria at the following levels:
  • In 20 percent of 24 healthy people
  • In 40 percent of 35 people with inflammatory bowel disease
  • In two-thirds of 21 people with colorectal cancer.
    These are small samples, but if the rates hold up for the whole population, the findings indicate that people with IBS and colorectal cancer are infected with this damaging strain ofE. coli at much higher rates.

    The findings also indicate that many healthy people harbor this bug with no apparent problems. I'm willing to venture they can do this because they have strong immune systems plus plenty of "good" gut bacteria to keep the "bad" bacteria in check.

    As to how the colibactin-producing bacteria lead to cancer—Jobin's team isn't completely sure.

    One thought is that gut inflammation causes colibactin-producing strains to multiply.

    At the same time, these proteins can cause cells lining the stomach to weaken—leaving them wide open to DNA damage.

    Given enough time, cells subjected to these conditions can turn cancerous.

    In essence, the study results suggest a direct link between changes in the gut microbiome (the total ecosystem of gut bacteria) and the development of inflammation and cancer.

    Jobin said doctors could possibly construct a personalized plan for cancer prevention for each patient. This would involve using DNA sequencing to find microbes in a patient's guts that could produce cancer-causing genes.

    The doctors could then use antibiotics to eliminate these microbes or encourage the use of probiotics to destroy cancer promoting bacteria. Readers of this newsletter know I'm opposed to the use of antibiotics in all but the most dire circumstances.

    The use of probiotics plus healthy eating habits (more fresh fruits and vegetables, few refined carbs) should create a healthy balance of gut bacteria in most people.

    It's important to understand that ALL of us have disease-causing microbes in our bodies, and we handle them just fine if we eat right and support our immune system.
Scientists across the pond have found a
different way to use E. coli
    Remember, there are various strains of the E. coli bacteria. British researchers are working on a genetically altered strain of the virus as a possible treatment.

    Their idea is to tinker with an E.coli bacterium to make it target and destroy cancer tumors.

    Scientists at the Queen Elizabeth Hospital in Birmingham have managed to alter one strain of the virus to make it harmless to healthy human cells—while serving as an assassin to cancer cells.

    A Daily Mail article describes how doctors used a common cold virus to deliver the E. colibacteria to the cancer cells.

    Simply put, the scientists have managed to arrest the poisons in E. coli until they reach the inside of cancer cells.

    According to Dr. Nick James, the oncologist who coordinated the therapy trials, the researchers are targeting men who have been treated for prostate cancer, but experienced a recurrence of the disease.

    Additional trials are underway to determine how this therapy could be helpful to patients with cancers of the head and neck, kidneys and liver.

    So depending on the strain, E.coli may be either a cancer cause or a cancer cure. More research is needed on both angles before we know for sure. But you can be sure that eating plenty of whole grains, fruits and vegetables is one of the best ways to sweep gunk out of your colon.

    Not only will it help you maintain a 'smooth move' in your bowels—but it could also help protect you from disease-producing germs and bacteria.

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